Immunohistochemical distinction of metastases of renal cell carcinoma with molecular analysis of overexpression of the chemokines CXCR2 and CXCR3 as independent positive prognostic factors for the tumorigenesis

(2016) Immunohistochemical distinction of metastases of renal cell carcinoma with molecular analysis of overexpression of the chemokines CXCR2 and CXCR3 as independent positive prognostic factors for the tumorigenesis. Iubmb Life. pp. 629-633. ISSN 1521-6543

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Abstract

Renal cell carcinoma (RCC) represents, on average, over 90 of all malignancies of the kidney that occur in adults in both sexes. Chemokine receptors expression has been found in many kinds of cancer and at tumor metastasis site. We determined CXCR2 and CXCR3 expression in RCC by immunohistochemistry method and analyzed the prognostic value of these markers. Our finding demonstrated that CXCR3 were highly overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P<0.001). The results showed that high expression of CXCR3 was markedly correlated with metastasis (P=0.021) and tumor stage (P=0.031). CXCR2 were overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P<0.001). Our result showed that CXCR2 expression was correlated with high grade (P=0.024), advanced stage (P=0.029) and metastasis (P=0.018). The log-rank test revealed that high CXCR2 and CXCR3 expressions are related to poorer overall survival (P<0.001; P<0.001). In conclusion, this study indicates the correlation of CXCR3 and CXCR3 with progression of RCC. In addition, high CXCR3 andCXCR2 expressions were correlated with shorter overall survival. (c) 2016 IUBMB Life, 68(8):629-633, 2016

Item Type: Article
Keywords: renal cell carcinoma cxcr3 and cxcr2 metastasis survival immunohistochemistry biological axis receptor cxcr3 lymph-nodes cancer expression angiogenesis melanoma growth
Page Range: pp. 629-633
Journal or Publication Title: Iubmb Life
Journal Index: ISI
Volume: 68
Number: 8
Identification Number: https://doi.org/10.1002/iub.1520
ISSN: 1521-6543
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/2509

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