(2022) Natural AMPK Activators in Cardiovascular Disease Prevention. Frontiers in Pharmacology. ISSN 16639812 (ISSN)
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Abstract
Cardiovascular diseases (CVD), as a life-threatening global disease, is receiving worldwide attention. Seeking novel therapeutic strategies and agents is of utmost importance to curb CVD. AMP-activated protein kinase (AMPK) activators derived from natural products are promising agents for cardiovascular drug development owning to regulatory effects on physiological processes and diverse cardiometabolic disorders. In the past decade, different therapeutic agents from natural products and herbal medicines have been explored as good templates of AMPK activators. Hereby, we overviewed the role of AMPK signaling in the cardiovascular system, as well as evidence implicating AMPK activators as potential therapeutic tools. In the present review, efforts have been made to compile and update relevant information from both preclinical and clinical studies, which investigated the role of natural products as AMPK activators in cardiovascular therapeutics. Copyright © 2022 Heidary Moghaddam, Samimi, Asgary, Mohammadi, Hozeifi, Hoseinzadeh‐Chahkandak, Xu and Farzaei.
| Item Type: | Article |
|---|---|
| Keywords: | AMPK atherosclerosis cardiovscular disease drug discovery natural products adenosine triphosphate arctigenin berberine chenxiang wan crocin curcumin ginsenoside ginsenoside Rb 1 ginsenoside Re ginsenoside Rg 3 herbaceous agent hydroxymethylglutaryl coenzyme A reductase kinase activator mammalian target of rapamycin complex 1 metformin microRNA naringenin natural product placebo pyrazine derivative qf 84139 quercetin resveratrol salvianolic acid B unclassified drug acute coronary syndrome AMPK signaling antiapoptotic activity antiinflammatory activity antioxidant activity autophagy (cellular) cardiovascular disease cell migration cell polarity coronary artery disease cytoskeleton diabetic cardiomyopathy dyslipidemia endoplasmic reticulum stress endothelial dysfunction gene mutation heart hypertrophy heart infarction heart muscle fibrosis heart muscle ischemia heart muscle metabolism heart protection heart ventricle remodeling hyperglycemia hyperlipidemia hypertension ischemic stroke metabolic regulation myocardial ischemia reperfusion injury non insulin dependent diabetes mellitus nonhuman protein synthesis Review transcription regulation |
| Journal or Publication Title: | Frontiers in Pharmacology |
| Journal Index: | Scopus |
| Volume: | 12 |
| Identification Number: | https://doi.org/10.3389/fphar.2021.738420 |
| ISSN: | 16639812 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/25214 |
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