Preemptive Effect of Adding Morphine to Topical lidocaine on Pain Intensity after Mastoidectomy-Tympanoplasty and Comparison with the Control Group

Abstract

Background: Due to the need to prevention of postoperative pain after mastoidectomy-tympanoplasty, the present study was performed to evaluate the preemptive effect of adding morphine to topical lidocaine on postoperative pain intensity. Methods: In this double-blind clinical trial study, 80 patients who were candidates for elective mastoidectomy-tympanoplasty surgery were randomly divided into two groups of 40; the first group underwent local anesthesia with lidocaine, and the second group underwent local anesthesia with lidocaine with morphine. Patients were evaluated for hemodynamic parameters, postoperative pain intensity during surgery and recovery and 24 hours after surgery, and the findings were compared between the two groups. Findings: Evaluation of patients' pain intensity in recovery and ward showed that at the time of patients' recovery and two hours after surgery, the intervention group had a lower intensity; but in 12 and 24 hours after surgery, no significant difference was seen between the two groups. In the intragroup study, pain intensity significantly reduced in both groups, but the rate of pain reduction in the intervention group was significantly higher. The trend of changes in hemodynamic parameters during surgery and length stay in recovery was not significantly different between the two groups. Conclusion: Addition of morphine to topical lidocaine reduces the postoperative mastoidectomy-tympanoplasty surgery, while topical use of this drug has no effect on patients' hemodynamics, longer recovery, and extubating time. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.