(2022) The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy. Molecular Biology Reports. pp. 10609-10615. ISSN 0301-4851
Full text not available from this repository.
Abstract
Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
| Item Type: | Article |
|---|---|
| Keywords: | Aquaporin 4 Glioma Glioblastoma Astrocytoma Meningioma central-nervous-system cancer-associated fibroblasts cell-proliferation peritumoral edema glioma expression migration apoptosis invasion glioblastoma Biochemistry & Molecular Biology |
| Page Range: | pp. 10609-10615 |
| Journal or Publication Title: | Molecular Biology Reports |
| Journal Index: | ISI |
| Volume: | 49 |
| Number: | 11 |
| Identification Number: | https://doi.org/10.1007/s11033-022-07656-y |
| ISSN: | 0301-4851 |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/25467 |
Actions (login required)
 |
View Item |