(2023) Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer. Journal of Drug Delivery Science and Technology. p. 13. ISSN 1773-2247
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Abstract
Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile.The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line.The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100, and the apoptosis value was higher (81) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies.
| Item Type: | Article |
|---|---|
| Keywords: | Anderson-type manganese polyoxomolybdate (MnMo6) Imidazolium modified chitosan (CSIm) Nanocomposite (NC) Anticancer activity Apoptosis Cell migration cellular uptake in-vitro polyoxometalate chitosan nanoparticles micelles peptide acid tumors assay Pharmacology & Pharmacy |
| Page Range: | p. 13 |
| Journal or Publication Title: | Journal of Drug Delivery Science and Technology |
| Journal Index: | ISI |
| Volume: | 87 |
| Identification Number: | https://doi.org/10.1016/j.jddst.2023.104778 |
| ISSN: | 1773-2247 |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/25912 |
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