(2023) Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 as a Potential Selective Anti-cancer Nano Platform. Journal of Inorganic and Organometallic Polymers and Materials. pp. 611-624. ISSN 1574-1443
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Abstract
A pH-sensitive nanoplatform of Pegylated Zeolitic Imidazolate Framework-8 (ZIF-8/PEG) was selected to modulate the cytotoxicity profile of arsenic polyoxotungstate (K6As2W18O62, KAW). The final nanoplatforms (NPs) showed a high loading content (31) and a pH-responsive release of KAW. The in vitro cytotoxicity experiments showed that the IC50 decreased to about half in designed NPs on MDA-MB-231 cancer cells with a better level of cellular uptake (92) than in control KAW (62). Also, the final pegylated NPs were safer than free KAW on normal cells (85 mg/mL versus 45 mg/mL). The in vitro study confirmed the higher potency of the designed NPs against breast cancer cells with lower side effects than free KAW. GRAPHICS .
| Item Type: | Article |
|---|---|
| Keywords: | Polyoxometalates (POMs) Arsenic Polyoxotumgstate (KAW) Zeolitic Imidazolate Framework-8 (ZIF-8) Breast Cancer Nano platforms (NPs) drug-delivery-systems zif-8 nanoparticles surface Polymer Science |
| Page Range: | pp. 611-624 |
| Journal or Publication Title: | Journal of Inorganic and Organometallic Polymers and Materials |
| Journal Index: | ISI |
| Volume: | 33 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.1007/s10904-022-02529-0 |
| ISSN: | 1574-1443 |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/25996 |
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