(2023) Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells. Clinical & Translational Oncology. pp. 2015-2042. ISSN 1699-048X
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Abstract
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
| Item Type: | Article |
|---|---|
| Keywords: | Cancer LncRNAs XIST Pathogenesis Tumorigenesis xist promotes proliferation exerts oncogenic functions epithelial-mesenchymal transition lung-cancer hepatocellular-carcinoma cisplatin resistance colorectal-cancer pancreatic-cancer suppresses proliferation clinical-significance Oncology |
| Page Range: | pp. 2015-2042 |
| Journal or Publication Title: | Clinical & Translational Oncology |
| Journal Index: | ISI |
| Volume: | 25 |
| Number: | 7 |
| Identification Number: | https://doi.org/10.1007/s12094-023-03110-y |
| ISSN: | 1699-048X |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/26372 |
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