Validity of the Adrogué-Madias Formula for the Management of Acute Dysnatremias in Critically Ill Children

Abstract

Validity of the Adrogue-Madias formula for the management of acute dysnatremias in critically ill children: a prospective multicenter analysis.ObjectiveCurrent conventional formulas do not predict the expected changes in serum sodium after administration of various fluids to correct serum sodium abnormalities. The Adrogue-Madias formula is currently the preferred and widely used fluid prescription for adult patients with dysnatremias, but its therapeutic efficacy has not been validated in pediatric patients.MethodsIn this prospective study, we used the Adrogue-Madias formula for calculating the appropriate rate of various fluids administration to correct serum sodium abnormalities in 7 critically ill children with acute dysnatremias.ResultsAfter administration of various intravenous fluids using the Adrogue-Madias formula, the anticipated as well as the achieved sodium concentrations were almost similar.ConclusionsThis study demonstrates that the use of the Adrogue-Madias quantitative formula allows to calculate the appropriate rate of administration of various fluids. The calculated fluid administration resulted in the subsequent actual laboratory values and clinical changes.