The effect of novel 3R,6R-bis (4-hydroxy benzyl) piperazine-2,5-dione (BHBPPD) derivatives on the expression of caspases in gastric cancer: A molecular docking and dynamics simulation

Abstract

2,5-Diketopiperazines show remarkable pharmaceutical potential. Growing cancer cases drive novel drug research, focusing on synthesizing an anticancer agent for gastric cells.The investigation centered on the effects of 3R,6R-bis (4-hydroxy benzyl) piperazine-2,5-dione (BHBPPD) on gastric cancer cells, with a specific emphasis on its role in inducing apoptosis. The study involved measuring of critical caspase expression levels, pivotal components of the apoptotic pathway. Utilizing geo-analysis, the research delved into the examination of the GSE4651 and GSE10262 datasets of to gastric cancer cells, intending to identify shared factors linked to the caspase activation pathway.