Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers

(2023) Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers. Anais Da Academia Brasileira De Ciencias. p. 14. ISSN 0001-3765

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Abstract

CRH neurons are found in the paraventricular nucleus (PVN) and central amygdala (CeA) nuclei. This study investigated the effects of sub-chronic CRH administration into the PVN and CeA nuclei on food intake biomarkers in rats divided into five groups: control, two shams, and two CRH-PVN and CRH-CeA groups (receiving CRH in nuclei for seven days). The CRH-PVN group had significantly higher cumulative food intake and food intake trends than the CRH-CeA group. The CRH-CeA and CRH-PVN groups exhibited significant increases in food intake during hours 1 and 2, respectively. Moreover, to be time-dependent, food intake is modulated by different brain nuclei. The CRH signaling pathway appeared to be activated later in the PVN than CeA. Both groups exhibited significantly higher leptin levels, the CRH-PVN group exhibited higher ghrelin levels and lower glucose levels. Repetitive administration of CRH into the PVN and CeA significantly reduced body weight differences. CRH administration into the PVN affected both leptin and ghrelin levels, but ghrelin had a greater impact on glucose variations and cumulative food intake than leptin. Finally, CRH administration into the PVN and CeA likely activated the HPA axis, and the CeA had a greater impact on the stress circuit than on food intake behavior.

Item Type: Article
Keywords: Central amygdala Corticotropin-releasing hormone Food intake Ghrelin Leptin Paraventricular nucleus corticotropin-releasing hormone body-weight behavioral-responses energy-expenditure stress ghrelin receptors dopamine leptin thermogenesis Science & Technology - Other Topics
Page Range: p. 14
Journal or Publication Title: Anais Da Academia Brasileira De Ciencias
Journal Index: ISI
Volume: 95
Number: 4
Identification Number: https://doi.org/10.1590/0001-3765202320200221
ISSN: 0001-3765
Depositing User: خانم ناهید ضیائی
URI: http://eprints.mui.ac.ir/id/eprint/26730

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