Immune-mediated necrotizing myopathy following vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine: A case report and brief review

(2023) Immune-mediated necrotizing myopathy following vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine: A case report and brief review. Revue Neurologique. pp. 630-635. ISSN 0035-3787

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Abstract

Immune-Mediated Necrotizing Myopathy (IMNM) after vaccination has been reported previously, however it is rare after COVID-19 vaccination. We report the first case of IMNM two weeks after vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine. There was a probable temporal relationship between the COVID-19 vaccination and the development of IMNM due to lack of known causative factors for IMNM. This may have been due to 1) autoimmunity directly caused by the vaccine, 2) exacerbation of autoimmunity triggered by the vaccine or 3) autoimmune syndrome triggered by the vaccine adjutants. Further studies are needed to assess the underlying mechanisms. # 2023 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Keywords: Myositis COVID-19 Vaccines Rhabdomyolysis Necrotizing autoimmune myopathy Neurosciences & Neurology
Page Range: pp. 630-635
Journal or Publication Title: Revue Neurologique
Journal Index: ISI
Volume: 179
Number: 6
Identification Number: https://doi.org/10.1016/j.neurol.2022.11.009
ISSN: 0035-3787
Depositing User: خانم ناهید ضیائی
URI: http://eprints.mui.ac.ir/id/eprint/27243

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