Plasma surface modification of electrospun polyhydroxybutyrate (PHB) nanofibers to investigate their performance in bone tissue engineering

(2023) Plasma surface modification of electrospun polyhydroxybutyrate (PHB) nanofibers to investigate their performance in bone tissue engineering. International Journal of Biological Macromolecules. p. 12. ISSN 0141-8130

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Abstract

Polyhydroxybutyrate (PHB) is a natural-source biopolymer of the polyhydroxyalkanoate (PHA) family. Nanofibrous scaffolds prepared from this biological macromolecule have piqued the interest of researchers in recent years due to their unique properties. Nonetheless, these nanofibers continue to have problems such as low surface roughness and high hydrophobicity. In this research, PHB nanofibers were produced by the electrospinning method. Following that, the surface of nanofibers was modified by atmospheric plasma. Scanning electron microscopy (SEM), water contact angle (WCA), atomic force microscopy (AFM), tensile test, and cell behavior analyses were performed on mats to investigate the performance of treated and untreated samples. The achieved results showed a lower water contact angle (from ?120 to 43), appropriate degradation rate (up to ? 20 weight loss in four months), and outstanding biomineralization (Ca/P ratio of ?1.86) for the modified sample compared to the neat PHB. Finally, not only the MTT test show better viability of MG63 osteoblast cells, but also Alizarin staining, ALP, and SEM results likewise showed better cell proliferation in the presence of modified mats. These findings back up the claim that plasma surface modification is a quick, environmentally friendly, and low-cost way to improve the performance of nanofibers in bone tissue engineering.

Item Type: Article
Keywords: Polyhydroxybutyrate (PHB) Electrospun scaffold Atmospheric plasma Tissue engineering mechanical-properties scaffolds fabrication behaviors membrane progress fiber Biochemistry & Molecular Biology Chemistry Polymer Science
Page Range: p. 12
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: ISI
Volume: 230
Identification Number: https://doi.org/10.1016/j.ijbiomac.2023.123167
ISSN: 0141-8130
Depositing User: خانم ناهید ضیائی
URI: http://eprints.mui.ac.ir/id/eprint/27475

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