The Effect of Different Fluid Therapy Methods on Hemodynamic Parameters, Blood Sugar, Blood Gases, and Blood Electrolytes in Six Months to Four Years Old Children Undergoing Surgery

Abstract

BACKGROUND: Considering the necessity of employing an appropriate fluid therapy for patients during the surgery to have hemodynamic stability and electrolyte balance and the lack of studies addressing children in this regard, the present study aimed at investigating the effect of different fluid therapy methods on hemodynamic parameters, blood sugar (BS), blood gases, and blood electrolytes in children undergoing surgery. MATERIALS AND METHODS: The current clinical trial was conducted on 105 children aged 6 months to 4 years that were candidates for surgery. These patients were randomly divided into three groups undergoing intraoperative fluid therapy with 1/5-4/5 serum, Ringer's, and 1/3-2/3 serum. The values of hemodynamic parameters, BS, serum electrolytes (sodium, potassium, and chloride), and blood gases (pH, HCO3, and BE) were evaluated and compared among the three groups. RESULTS: The level of BS at the end of the surgery in Ringer's group with mean 166.20 +/- 39.46 mg/dl was significantly lower than its level in the other two groups (1/5-4/5 serum: 241.00 +/- 51.11 and 1/3-2/3 serum: 189.20 +/- 34.23; P value < 0.05). Moreover, pH, HCO3, and BE at the end of the surgery had significant differences between the three groups (P value < 0.05). The amount of urine output at all follow-up times revealed a significant difference between Ringer's group and the other two groups (P value < 0.001). CONCLUSION: Use of Ringer's serum during anesthesia in children, in addition to maintaining BS and electrolytes within the normal range, has resulted in greater stability of hemodynamic responses and maintenance of the body's acid-base balance.