The salivary exosomal microRNA as a potential biomarker in patients with periodontitis and oral cancers

(2023) The salivary exosomal microRNA as a potential biomarker in patients with periodontitis and oral cancers. Chemical Biology & Drug Design. pp. 1204-1215. ISSN 1747-0285 (Electronic) 1747-0277 (Linking)

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Abstract

Periodontitis and oral cancers are the most common oral diseases in the human population. The early diagnosis of oral diseases allows the efficient therapy of the patient. During oral diseases, resident cells in the affected tissue secrete exosomal microRNAs (miRNAs) into saliva. As these miRNAs have a crucial role in the pathogenesis of oral diseases, they have been suggested as non-invasive and validated biomarkers in predicting periodontitis severity and cancer progression. Several attempts have been performed to evaluate the expression of salivary exosomal miRNAs in patients with periodontitis and oral cancers. Some miRNAs are differentially expressed in the saliva of the affected patients when compared to healthy individuals. These miRNAs are reviewed in this narrative review. Collectively, it seems that salivary exosomal microRNAs could be used as a diagnostic biomarker in oral diseases. However, further studies are required to validate them.

Item Type: Article
Keywords: Humans *MicroRNAs/metabolism Biomarkers/metabolism *Periodontitis/diagnosis *Mouth Neoplasms/diagnosis/genetics biomarker exosome microRNA oral cancers periodontal disease saliva
Page Range: pp. 1204-1215
Journal or Publication Title: Chemical Biology & Drug Design
Journal Index: Pubmed
Volume: 101
Number: 5
Identification Number: https://doi.org/10.1111/cbdd.14159
ISSN: 1747-0285 (Electronic) 1747-0277 (Linking)
Depositing User: خانم ناهید ضیائی
URI: http://eprints.mui.ac.ir/id/eprint/27800

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