(2023) The role of LncRNA MCM3AP-AS1 in human cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. pp. 33-47. ISSN 1699-3055 (Electronic) 1699-048X (Linking)
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Abstract
Long noncoding RNAs (lncRNA) play pivotal roles in every level of gene and genome regulation. MCM3AP-AS1 is a lncRNA that has an oncogenic role in several kinds of cancers. Aberrant expression of MCM3AP-AS1 has been reported to be involved in the progression of diverse malignancies, including colorectal, cervical, prostate, lymphoma, lung, ovary, liver, bone, and breast cancers. It is generally believed that MCM3AP-AS1 expression is associated with cancer cell growth, proliferation, angiogenesis, and metastasis. MCM3AP-AS1 by targeting various signaling pathways and microRNAs (miRNAs) presents an important role in cancer pathogenesis. MCM3AP-AS1 as a competitive endogenous RNA has the ability to sponge miRNA, inhibit their expressions, and bind to different target mRNAs related to cancer development. Therefore, MCM3AP-AS1 by targeting several signaling pathways, including the FOX family, Wnt, EGF, and VEGF can be a potent target for cancer prediction and diagnosis. In this review, we will summarize the role of MCM3AP-AS1 in various human cancers.
| Item Type: | Article |
|---|---|
| Keywords: | Male Female Humans *RNA, Long Noncoding/genetics/metabolism *MicroRNAs/genetics *Breast Neoplasms/genetics Signal Transduction Liver Gene Expression Regulation, Neoplastic Cell Proliferation Acetyltransferases/genetics/metabolism Intracellular Signaling Peptides and Proteins/genetics Cancer Long non-coding RNAs Mcm3ap-as1 Signaling pathways miRNAs |
| Page Range: | pp. 33-47 |
| Journal or Publication Title: | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico |
| Journal Index: | Pubmed |
| Volume: | 25 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1007/s12094-022-02904-w |
| ISSN: | 1699-3055 (Electronic) 1699-048X (Linking) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/27836 |
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