A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (PGS)/Gelatin with Local Delivery of Ascorbic Acid and Pantothenic Acid

Abstract

Skin wounds can lead to numerous problems with dangerous health consequences. One of the best treatments for chronic wounds is using novel wound dressings containing drugs and vitamins to improve healing. In this study, Poly (Glycerol Sebacate) (PGS)/Gelatin wound dressing, containing vitamin B5 and vitamin C, was fabricated by electrospinning. In addition, the fabricated dressing’s structure, physical properties, drug release, antibacterial activity, and cytotoxicity were evaluated. Results revealed that the diameter of the fibers PGS-G/VitB5 was 603.155 ± 12.09 nm. Furthermore, the degradation results showed that about 20 of cross-linked PGS-G/Vit B5/Vit C was degraded during 14 days but could maintain its stability well. The water absorption and contact angle of cross-linked PGS-G/Vit B5/Vit C were 605 and 52°, respectively. Moreover, the vitamins C and B5 releases demonstrated the burst release during 1 and 6 h, respectively. Antibacterial results also demonstrated that vitamin B5 in PGS/gelatin wound dressing could prevent gram-negative and gram-positive bacteria growth. According to the cell viability assay, vitamin C enhanced cell adhesion and cell proliferation. Finally, a suitable wound healing product was recommended with the PGS/gelatin with vitamin C/vitamin B5 wound dressing with ideal biological properties. Graphical abstract: Figure not available: see fulltext. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.