Evaluation of lipid nanocarriers in the form of SLN and their application in drug delivery

Abstract

Currently, most drugs reach to their place where they can have their desired effects through traditional methods and systemic absorption. Drugs are associated with many problems and complications in drug delivery systems the aim of which is reducing the frequency of drug usage and optimizing the effect of the drug. Therefore, by providing effective drug concentrations in the damaged organ, the therapeutic effect of the drug is enhanced and its degradation is reduced. In addition, this maintains the circulation of the drug in the blood for a longer time and can diminish its side effects. There are different types of drug delivery systems (DDS) of most advanced types for nanostructured carriers in design and fabrications. Solid lipid nanoparticles (SLN) form colloidal drug carrier systems are an alternative to colloidal carriers such as liposomes, emulsions, and micro polymeric components. For the synthesis of these particles, many methods are applied which provide the possibility of loading various hydrophobic and hydrophilic drugs inside the lipid nanoparticles. In this article, various methods and application of these lipids in targeted drug delivery system are reviewed. © 2023, Iranian Chemical Society. All rights reserved.