(2023) Riboflavin and Histidine Metabolisms Are Two Key Pathways Related to the Clinically Isolated Syndrome (CIS): A WGCNA-based In silico Analysis. Current Pharmacogenomics and Personalized Medicine. pp. 57-71. ISSN 18756921 (ISSN)
Full text not available from this repository.
Abstract
Background: As an inflammatory disorder, Multiple Sclerosis (MS) causes de-myelination, as well as axonal and neuronal injury in the central nervous system (CNS). Several clinical signs may be the indicators of MS among which, Clinically Isolated Syndrome (CIS) is the first symptom caused by the inflammation and demyelination of CNS. CIS is characterized by symptoms such as optic neuritis, brain stem or cerebellar syndrome, spinal cord syndrome, or sometimes cerebral hemispheric dysfunction. Objective: So far, metabolic pathways involved in the development of CIS are not fully un-derstood. Therefore, in this study, weighted gene co-expression network analysis (WGC-NA) has been used to identify differentially expressed genes in CIS disease and the main pathways associated with it. Methods: We grouped differentially expressed genes along with the functionally related genes into large modules to obtain their direct and indirect relationships. Results: The results have identified two new pathways associated with CIS, including riboflavin and histidine metabolism-involved pathways. Conclusion: Riboflavin and histidine metabolism-involved pathways may be considered potential therapeutic goals for CIS management in the future. © 2023 Bentham Science Publishers.
| Item Type: | Article |
|---|---|
| Keywords: | clinically isolated syndrome (CIS) CNS immunity-involved pathways MRI multiple sclerosis (MS) WGCNA acid phosphatase 5 adhesion g protein coupled receptor e5 alkb homolog 6 biological marker carnosine n methyltransferase 1 cell division cycle 23 homolog chromosome 9 open reading frame 40 coatomer subunit epsilon coiled coil domain containing 69 cytochrome c oxidase assembly factor 6 glycogen debranching enzyme histidine inhibitor of bruton tyrosine kinase integrin subunit alpha 5 ligand dependent nuclear receptor corepressor llgl scribble cell polarity complex component 2 protein melanoma antigen family f1 mif4g domain containing protein mis18 kinetochore protein a morc family cw type zinc finger 4 nucleic acid binding protein 1 phosphotriesterase related protein proteasomal ubiquitin receptor adrm1 pyruvate dehydrogenase complex component x riboflavin ring finger protein 149 ring finger protein 25 small nuclear ribonucleoprotein polypeptide e thioredoxin domain containing 11 trafficking protein particle complex subunit 6b transmembrane protein 87b tyw3 protein udp n acetylglucosamine transferase subunit alg14 unclassified drug zinc finger and btb domain containing 41 zinc finger dhhc type palmitoyltransferase 13 zinc finger mym type containing 1 like zinc finger protein 519 Article central nervous system computer model demyelinating disease differential gene expression functional enrichment analysis histidine metabolism human immunity involved pathways metabolism microarray analysis multiple sclerosis nuclear magnetic resonance imaging pathway enrichment analysis riboflavin metabolism weighted gene co expression network analysis |
| Page Range: | pp. 57-71 |
| Journal or Publication Title: | Current Pharmacogenomics and Personalized Medicine |
| Journal Index: | Scopus |
| Volume: | 20 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.2174/1875692120666230504114225 |
| ISSN: | 18756921 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/28253 |
Actions (login required)
 |
View Item |