(2023) Neuropsychiatric Manifestations of COVID-19 in Hospitalized Pediatrics: A Multicenter Cross-sectional Study. Archives of Pediatric Infectious Diseases. ISSN 23221828 (ISSN)
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Abstract
Background: The large proportion of coronavirus disease 2019 (COVID-19) patients has been associated with a large number of neu-ropsychiatric manifestations. Despite the high prevalence of COVID-19, few studies have examined such manifestations, especially in children and adolescents. Objectives: This study investigated neuropsychiatric manifestations in hospitalized children and adolescents admitted for COVID-19 infection in Iran. Methods: This prospective observational study included admitted children and adolescents (4-18 years old) diagnosed with COVID-19 infection, pediatric neurologists, child and adolescent psychiatrists, and infectious disease specialists, and assessed 375 infected patients during August and December 2021. Results: Of the 375 patients, 176 (47) were female, with a mean age of 9.0 ± 3.39 years. Psychiatric and neurological manifestations were reported in 58 (15.5) and 58 (15.5) patients, respectively. The most prevalent psychiatric disorders were separation anxiety disorder (SAD) (5.1), major depressive disorder (MDD) (3.5), generalized anxiety disorder (GAD) (2.7), insomnia (2.4), and op-positional defiant disorder (ODD) (2.4). Regarding neurological complications, seizures were the most prevalent (13.1), followed by encephalitis (1.9), transverse myelitis (0.3), acute ischemic stroke (0.3), and Guillain-Barre syndrome (0.3). There was no significant relationship between the duration of COVID-19 infection (P = 0.54) and ICU admission (P = 0.44) with the emergence of psychiatric symptoms. Conclusions: The most prevalent neurologic and psychiatric complications among children and adolescents with COVID-19 infection were seizures and the symptoms of anxiety/mood disorders, respectively. © 2023, Author(s).
| Item Type: | Article |
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| Keywords: | Adolescent Anxiety Disorder Child COVID-19 Neuropsychiatric Complication Seizure anticonvulsive agent antimalarial agent antitussive agent antivirus agent C reactive protein corticosteroid immunoglobulin interferon nonsteroid antiinflammatory agent sedative agent acute ischemic stroke acute lymphoblastic leukemia adrenoleukodystrophy adult anxiety Article Babinski reflex basal ganglion brain brain edema carcinomatous meningitis caregiver cerebrovascular accident cervical disk hernia Child Behavior Checklist child hospitalization comorbidity computer assisted tomography consciousness level controlled study coronavirus disease 2019 cross-sectional study diabetic ketoacidosis Diagnostic and Statistical Manual of Mental Disorders electroencephalogram encephalitis epilepsy epileptic state fatigue female fever gait generalized anxiety disorder Guillain Barre syndrome hemodynamic stress hospitalization human hydrocephalus hypercapnia hypoxemia insomnia Iran ischemic stroke lymphocytopenia major clinical study major depression male medical history mental disease metachromatic leukodystrophy mood disorder muscle tone neurologic examination neurological complication neurologist nuclear magnetic resonance imaging observational study oppositional defiant disorder oxygen saturation phobia physical examination polymerase chain reaction practice guideline prevalence prospective study psychiatric complication reverse transcription polymerase chain reaction school child separation anxiety systemic inflammatory response syndrome thorax radiography thrombocytopenia tomography transverse myelitis upper respiratory tract infection visual evoked potential |
| Journal or Publication Title: | Archives of Pediatric Infectious Diseases |
| Journal Index: | Scopus |
| Volume: | 11 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.5812/apid-131511 |
| ISSN: | 23221828 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/28321 |
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