The Impact of Deep Local Lung Hyperthermia on COVID-19 Cancer Patients

Abstract

Background: The goal of this study was to assess the impact of deep local hyperthermia on oxygen (O-2) saturation and infected volumes of lungs on coronavirus disease 2019 (COVID-19) cancer patients. Materials and Methods: Fifty patients who suffered from COVID-19 (according to their computed tomography (CT) images and laboratory findings) were included in this study. The mentioned patients were divided into two groups (I and II) with thirty-five participants. The infected volumes and COVID-19 infectious locations were diagnosed using their CT images, and deep local hyperthermia was performed for group II. After three consequent days, the SPO2, D-dimer, and infected volumes of lung parenchyma of both groups were compared to each other. Results: For group II, the mean +/- SD (standard deviation) of O-2 pressure saturation (SPO2) before/after hyperthermia was 85 +/- 0.0/91.3 +/- 0.5, respectively, while for group I, the mean +/- SD of SPO2 before/after 3 days was 85 +/- 0.0/88 +/- 0.2, respectively. For infected volumes of lungs before/after hyperthermia in group II, the mean +/- SD was 31.36 +/- 3.13/4 +/- 1.53, respectively. Nonetheless, the infected volumes of lungs for group I were 34.21 +/- 3.41/10 +/- 2.12 before/after three days. For group II, the amount of D-dimer before/after hyperthermia was 3200 +/- 106/510 +/- 121, respectively. However, for group I, it was 3100/740 before/after the consequent three days, respectively. Conclusion: Deep local lung hyperthermia for COVID-19 cancer patients is suggested, as a result of its positive impacts on SPO2 improvement and also D-dimer serum level, C-reactive protein, and Lactate dehydrogenaze reduction for the mentioned patients.