Span of spleen is associated with disability status in multiple sclerosis: a cross-sectional abdominopelvic ultrasonography study

(2024) Span of spleen is associated with disability status in multiple sclerosis: a cross-sectional abdominopelvic ultrasonography study. Scientific Reports. p. 11. ISSN 2045-2322

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Abstract

Characteristics of livers and spleens of people with multiple sclerosis (pwMS) could constitute good biomarkers of MS-related characteristics such as the disability status. To test the hypothesis "the gross anatomical features of livers and spleens, are not similar between pwMS with different disease characteristics" a cross-sectional study was conducted on pwMS seen at the Isfahan MS clinic, Iran, from February until December 2023. Definitive, otherwise-healthy, pwMS were enrolled after an initial laboratory evaluation. Presence/absence and grading of non-alcoholic fatty liver disease (NAFLD) and the span of spleen were determined by a radiologist using high-resolution abdominopelvic ultrasonography. 193 pwMS (160 women) were enrolled. Of whom, 143 (74.1) were receiving first-line disease-modifying therapies (DMTs), 24 (12.4) fingolimod, and 26 (13.5) rituximab. The span of spleen was negatively associated with EDSS (adjusted beta SE - 4.08 1.52, p < 0.01), as well as 6 m-CDW (adjusted beta SE - 6.94 3.56, p = 0.05), unlike age, DMTs, and MS duration (all with p > 0.05). Receiver operating characteristic analysis showed, spleen span performs significant but poor in discrimination of EDSS > 1 from EDSS = 1 (area under curve AUC 0.62, SE 0.05, p < 0.01), yet, significant and fair in discrimination of presence from absence of 6 m-CDW (AUC 0.72, SE 0.06, p < 0.01). Other findings were unremarkable. Further longitudinal, prospective studies are warranted to confirm whether smaller spleens are predictive of higher disability accrual rate in pwMS. Particularly, findings require further validation in untreated/treatment-na & iuml;ve pwMS, and ones with higher EDSS scores.

Item Type: Article
Keywords: abnormalities disease Science & Technology - Other Topics
Page Range: p. 11
Journal or Publication Title: Scientific Reports
Journal Index: ISI
Volume: 14
Number: 1
Identification Number: https://doi.org/10.1038/s41598-024-66216-5
ISSN: 2045-2322
Depositing User: خانم ناهید ضیائی
URI: http://eprints.mui.ac.ir/id/eprint/29239

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