Investigating the comparative effect of vitamin D level with the type of complications in Henoch Schönlein purpura and Kawasaki disease

Abstract

Introduction and objectives: Henoch Sch & ouml;nlein purpura (HSP) and Kawasaki disease (KD) are two inflammatory diseases among childhood vasculitis. Considering the anti-inflammatory effects of hydroxyvitamin D3, we decided to investigate the association of serum 25-hydroxy vitamin D3 with the type and severity of these conditions. Materials and methods: The present study was performed as a historical cohort of 254 affected children with KD and HSP vasculitis. The required data were extracted, using a researcher-made questionnaire from patients' electronic file, and then they were analyzed after collecting information of the patients. Results: In HSP group, 54 of participants were boys. Similarly, in KD group, boys were more affected than girls. The comparative 25-hydroxyvitamin vitamin D3 level in HSP patients with and without involvement ( P = 0.02), hematuria ( P = 0.14), and in two groups with and without heart disease, and with and without coronary artery dilatation in KD patients ( P < 0.001) were significant. Discussion and conclusions: The findings showed that insufficient level of vitamin D3 were significantly associated with the exacerbation of complications of both diseases, and therefore it seems that vitamin D deficiency can be an effective predictive factor of severity in HSP and KD patients. (c) 2024 Published by Elsevier Espana, S.L.U.