Deep eutectic solvents (DESs) in microextraction of Parabens: A review

Abstract

Parabens (PBs) are a class of chemical compounds that can cause malignant melanoma through their estrogenic and genotoxic effects. Thus, quantification of PBs in pharmaceuticals, foods and waters is crucial. Due to large enrichment factors, rapidity, simplicity, cost-effectiveness, and minimal use of organic solvents, microextraction has been employed for the pre-concentration and extraction of PBs. Deep Eutectic Solvents (DESs) have emerged as a novel class of green solvents, offering promising applications in various fields, including microextractions. This review describes and discusses application of DESs in microextraction of parabens, focusing on their environmental benefits, and efficiency compared to traditional solvents. Articles available online up to the end of January 2024 were assembled, curated and advantages and disadvantages of each method are described.