How Do Genetic and Environmental Factors Influence Cardiometabolic Risk Factors? Findings from the Isfahan Twins Study

Abstract

Background: Disease -discordant twins are excellent subjects for matched case -control studies as they allow for the control of confounding factors such as age, gender, genetic background, and intrauterine and early environment factors. Study design: A cross-sectional study. Methods: Past medical history documentation and physical examination were conducted for all participants. Fasting venous blood samples were taken to measure fasting blood glucose (FBG) and lipid levels. The ACE model, a structural equation model, was used to assess heritability. Results: This study included 710 twin pairs (210 monozygotic and 500 dizygotic) ranging in age from 2 to 52 years (mean age: 11.67 +/- 10.71 years). The study was conducted using participants from the Isfahan Twin Registry (ITR) in 2017. Results showed that in early childhood (2-6 years), height, weight, and body mass index (BMI) were influenced by shared environmental factors (76, 75, and 73, respectively). In late childhood (7-12 years), hip circumference, waist circumference (WC), and low -density lipoprotein (LDL) cholesterol were found to be highly heritable (90, 76, and 64, respectively). In adolescents, height (94), neck circumference (85), LDL-cholesterol (81), WC (70), triglycerides (69), weight (68), and BMI (65) were all found to be highly or moderately heritable. In adult twins, arm circumference (97), weight (86), BMI (82), and neck circumference (81) were highly heritable. Conclusion: This study demonstrates that both genetic and environmental factors play a role in influencing individuals at different stages of their lives. Notably, while certain traits such as obesity have a high heritability during childhood, their heritability tends to decrease as individuals transition into adulthood.