Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats

Abstract

Background & Objective: Liver damage is a common complication of lithium (Li). The present study investigates the preventive role of MgSo4 and moderate-intensity training MIT on Li hepatotoxicity in male rats. Materials & Methods: Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10 formalin to be sent to the lab for pathological investigations. Results: Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05. Conclusion: MgSo4 and exercise reduce Li-related, improved integrity together with liver function. © 2024, Zanjan University of Medical Sciences and Health Services. All rights reserved.