(2024) Effect of nutrition adequacy on inflammation, respiratory improvement, and success of weaning from mechanical ventilation in critically ill patients: A single-blind randomized controlled clinical trial. Clinical Nutrition Open Science. pp. 227-238. ISSN 26672685 (ISSN)
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Abstract
Background: This prospective interventional study aimed to investigate the effect of nutritional adequacy through a multidisciplinary approach on the success of ventilator weaning in patients admitted to ICU considering patients' nutritional status at baseline and monitoring nutritional measurements during the study. Materials and methods: In this randomized, single-blind, two-arm clinical trial (IRCT20201229049876N1, Registration date: 2021-01-06), subjects were selected from patients undergoing mechanical ventilation and admitted to the intensive care unit (ICU) of three medical centers between January 2021 and June 2022. The intervention group received multidisciplinary nutritional support rounds twice weekly, while the control group received the usual nutrition therapy (physician-centered NS). Results: Our results showed that 92 of patients in the intervention group had a higher daily energy intake (≥80 of goal Kcal) compared with the control group, 62 of patients (P≤ 0.05). There were no significant differences in terms of BMI, and values of respiratory function parameters between the two groups (all P> 0.1) at the end of the study. However, the mean score of the Burns Wean Assessment Program (BWAP), and circulating levels of C-reactive protein were significantly changed in the interventional group than in the control group. Conclusion: Applying a multidisciplinary nutrition support program could improve nutrition adequacy, CRP levels, and the BWAP score in ventilated ICU patients. © 2024 The Author(s)
| Item Type: | Article |
|---|---|
| Keywords: | Mechanical ventilation Multidisciplinary nutrition delivery Weaning time albumin bicarbonate C reactive protein calcium creatinine glucose hemoglobin magnesium nitrogen phosphorus potassium sodium urea adult albumin blood level APACHE Article artificial ventilation bicarbonate blood level blood oxygen tension body mass breathing rate Burns Wean Assessment Program score calcium blood level caloric intake clinical article clinical outcome collaborative care team controlled study creatinine blood level critical illness critically ill patient diet therapy enteric feeding female fraction of inspired oxygen glucose blood level health care delivery hematocrit hemoglobin blood level hospital admission human inflammation intensive care unit intervention study laboratory test lymphocyte count magnesium blood level male middle aged multicenter study nutrition adequacy nutritional assessment Nutritional Risk Screening score nutritional status nutritional support parenteral nutrition patient monitoring patient selection peak inspiratory pressure peripheral oxygen saturation physician positive end expiratory pressure ventilation potassium blood level prospective study protein blood level randomized controlled trial respiratory function respiratory tract parameters scoring system Sequential Organ Failure Assessment Score single blind procedure sodium blood level therapy effect tidal volume treatment duration urea nitrogen blood level ventilator weaning |
| Page Range: | pp. 227-238 |
| Journal or Publication Title: | Clinical Nutrition Open Science |
| Journal Index: | Scopus |
| Volume: | 58 |
| Identification Number: | https://doi.org/10.1016/j.nutos.2024.09.006 |
| ISSN: | 26672685 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/30482 |
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