Effect of L-Arginine Supplementation on Sexual Function and Hypogonadism in Men with Type 2 Diabetes

Abstract

Background: A negative correlation has been seen between serum testosterone levels and glycosylated hemoglobin. L-arginine reduces serum glucose and cholesterol levels in diabetes. Therefore, this study aimed to determine the effect of L-arginine on sexual function and hypogonadism. Methods: In this clinical trial study, 50 men with type 2 diabetes and symptoms of hypogonadism were randomly divided into two groups. Demographic and laboratory information and International Erectile Dysfunction Questionnaire 5 (IIEF5) were completed in both groups. Then, the first group received an oral L-arginine 3 gram single dose per day for 8 weeks, and the second group received a placebo vial for 8 weeks. We compared the primary outcomes, including total and free testosterone plasma levels, as well as secondary outcomes, such as Sexual function and symptoms of hypogonadism between the two groups. Findings: In the L-arginine group, after 8 weeks of intervention, sexual performance (36.43 ± 3.84 to 28.44 ± 11.4, P = 0.001) and free testosterone plasma level (19.16 ± 0.07 to 22.21 ± 1.25, P = 0.001) (79.6 ± 35.2 to 78.8 ± 11.3, P = 0.031) significantly increased While there were no significant changes in the placebo group (P ≥ 0.05). side effects (P ≥ 0.05). did not show significant differences between the two groups. Conclusion: Oral L-arginine is effective on sexual performance and symptoms of hypogonadism in type 2 diabetic men. Therefore, L-arginine can be a suitable alternative to testosterone in the treatment of hypogonadism in men with type 2 diabetes. © 2024 Isfahan University of Medical Sciences(IUMS). All rights reserved.