Incidence of Chemotherapy-Induced Fever and Neutropenia in Different Chemotherapy Regimens in Hospitalized Patients with Non-Metastatic Breast Cancer

Abstract

Background and Objective: Chemotherapy-induced fever and neutropenia are side effects of chemotherapy regimens that, in addition to disrupting the treatment process of patients, threaten their health as well. In this study, the prevalence of chemotherapy-induced fever and neutropenia in different chemotherapy regimens in hospitalized patients with non-metastatic breast cancer was investigated. Materials and Methods: In this descriptive crosvsectional study, a total of 200 adult patients hospitalized at Seyed al-Shohada (Omid) Hospital in Isfahan, Iran, from 2016 1o 2021 due to breast cancer were selected. These tatients had receiver! chemotherapy regimens including AC, AC-T, and TAXAN'E. The data were extracted from the breast cancer registry and the hospital's HIS systems and analyzer! with the SPSS software at a 95% confidence level. Results: The mean age of the patients was 46.90±l 1.28 years. The frequency of chemotherapy-induced neutrojrenia and fever was 15.5% and 9.5%, respectively. A significant relationship was olrserved Ix’lween chemotherapy-induced fever and neutro|>enia with older age, higher cancer stage, and hypertension (P<0.05 for all). However, no significant relationship was found Ijetween the type of chemotherapy regimen and diabetes. Conclusion:Chemotherapy-induced neutro|>enia and fever caused by neutropenia are relatively common side effects in breast cancer chemotherapy regimens. Older age, higher stage of cancer, and hypertension increased the prevalence of chemotherapy-induced neutro|x>nia and neutropenia-induced fever. © 2024 Avicenna Journal of Nursing and Midwifery Care.