Comparison of Serum Levels Free and Total Prostate Specific Antigen in Women with Colorectal Cancer and Healthy Women

Abstract

Background: Prostate-specific antigen has been reported in non-prostate cancer tissues such as the breast, ovary, endometrium, kidney, adrenal, liver, salivary glands, and esophagus, as well as in colon cancer tissues. The study aimed to compare the serum level of the above antigen in women with colorectal cancer and the control group. Methods: In this case-control study, 17 female patients with colorectal cancer and 17 healthy women who were admitted to Al-Zahra Hospital in Isfahan during 2021-2022 were selected and compared in terms of prostate-specific antigen levels. Findings: The median free PSA level in the case group was 0.01 (0.005-0.01), and in the control group was 0.008 (0.007-0.009) (P < 0.001), and the median total PSA level in the two groups was 0.012 (0.007-0.04) and 0.001 (0.001-0.005) ng/dL, respectively (P > 0.001) and the difference between the two groups was significant. Conclusion: In this study, total and free PSA levels in women with colorectal cancer were significantly higher than healthy women. Total and free PSA serum levels decreased with age, but this inverse correlation was not statistically significant. There was no significant correlation between total and free PSA serum levels and the location or stage of tumors. Measurement of PSA level in women with colorectal cancer may be helpful in the diagnosis of biopsy and applicable for early diagnosis of the disease © 2024 Isfahan University of Medical Sciences(IUMS). All rights reserved.