Investigating the Relationship between the Severity of Restless Leg Syndrome and the Type of Dialysis and Blood Parameters of Calcium, Phosphorus, Parathyroid Hormone, and Vitamin D

Abstract

Background: Restless leg syndrome (RLS) is a common complication of chronic kidney disease (CKD). Due to the ambiguity of the pathophysiology of this condition, the effect of the dialysis method and the relationship between the serum level of blood parameters and the severity of RLS incidence have not been well defined. In this study; the relationship between the dialysis method and the effect of blood calcium, phosphorus, parathyroid hormone, and vitamin D on the severity of restless leg syndrome has been investigated. Methods: In this cross-sectional study, 165 hemodialysis patients and 110 peritoneal dialysis patients were included by referring to the dialysis department of Al-Zahra and Khurshid Hospital in Isfahan. Restless leg syndrome was diagnosed and ranked using international criteria, then the parameters of vitamin D, calcium, phosphorus, and parathyroid hormone were recorded and analyzed based on the results of the tests. Findings: The results of the present study show that the dialysis method does not affect the frequency and severity of restless leg syndrome. In this research, the multiple regression model did not fit well in the hemodialysis and peritoneal dialysis groups. Based on the results, the correlation values between calcium, PTH, and serum phosphorus variables in the two groups were positive, and the relationship between vitamin D and restless legs syndrome score was negative (P < 0.05). Conclusion: Regularly monitoring biochemical markers such as vitamin D, phosphorus, calcium, and PTH levels in the blood serum of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) patients plays a crucial role in reducing the occurrence of restless leg syndrome in CKD patients. © 2024 Isfahan University of Medical Sciences(IUMS). All rights reserved.