(2024) Fabrication of a tri-layer scaffold with dual release of heparin and PRP for tissue engineering of small‐diameter blood vessels. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 1374-1385. ISSN 00914037 (ISSN)
Full text not available from this repository.
Abstract
A tri-layer scaffold was fabricated according to functionally graded materials (FGM) theory from poly(glycerol sebcate)/poly(L-lactic acid) blend by the increasing polylactic acid ratio from the inner to the outer layer. Heparin and platelet-rich plasma were loaded in separate layers to achieve proper remodeling and patency. The scaffold showed a linear degradation trend. The elastic modulus was 13.8 ± 1.11 Mpa that was in the favorable range for constructing artificial vessels. The integrity of the layers was preserved due to its FGM structure. The scaffold showed full blood compatibility by minimal platelet adhesion and hemolysis due to relatively slow release of Heparin. © 2023 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | Biomimetic drug release hemocompatibility tEVG tri-layer scaffold Biomimetics Blood vessels Controlled drug delivery Functionally graded materials Lactic acid Platelets Polysaccharides Scaffolds (biology) Targeted drug delivery Acid ratio Dual release Haemocompatibility Materials theories Poly-l-lactic acids Tissues engineerings Trilayers Fabrication |
| Page Range: | pp. 1374-1385 |
| Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Journal Index: | Scopus |
| Volume: | 73 |
| Number: | 16 |
| Identification Number: | https://doi.org/10.1080/00914037.2023.2289537 |
| ISSN: | 00914037 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/30827 |
Actions (login required)
 |
View Item |