The Effect of Vitamin D Deficiency on Liver Transplant Recipients

Abstract

Liver disease, which leads to end-stage organ dysfunction, is becoming one of the top causes of death worldwide. Many molecular and cellular pathways affect liver transplant such as tissue maintenance or rejection. Low 25-dihydroxyvitamin D levels are linked to numerous chronic disorders, including end-stage liver disease. We conducted a thorough search of five major academic databases (ScienceDirect, PubMed, Medline, Google Scholar, and Scopus) for articles published by November 4, 2023. The research was carried out utilizing the seven processes delineated in the Cochrane Handbook. The search for studies involved the use of different keywords, including "Vitamin D," "deficiency," and "liver transplantation." This study analyzed 14 papers that examined Vitamin D levels after liver donation (among the liver's recipients). The research's findings revealed that patients with normal Vitamin D levels had a greater rate of recovery after surgery, a stronger immune system, and a lower severity of the risk of transplant rejection than those with Vitamin D deficiency. In general, Vitamin D supplementation before or after liver transplantation can reduce the risk of infection and increase the survival rate in these patients without any toxic effects at standard doses.