The Effectiveness of Phytosomal Curcumin on Inflammation in Patients with Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial

Abstract

Background: Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on CRP in critically ill patients with multiple traumas. Methods: In this double-blind trial, 53 patients with multiple trauma who were admitted to the intensive care unit (ICU) were randomized to receive either two capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or two identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory parameters were assessed before and after the intervention. Findings: After seven days of intervention, quantitative C-reactive protein (CRP) (P = 0.044) levels significantly decreased in the curcumin compared with the placebo group. Conclusion: Phytosomal curcumin had a beneficial effect on laboratory factor (CRP) in ICU-admitted patients with multiple trauma. © 2025 Isfahan University of Medical Sciences(IUMS). All rights reserved.