Introduction to the Stir Bar Sorptive Extraction Method and its Applications in Occupational Toxicology

Abstract

Sample preparation is a crucial step in chemical analysis. Stir Bar Sorptive Extraction (SBSE) is one of the sample preparation methods employed in this field. This article provides an overview of the SBSE method and reviews its applications in toxicology. It discusses the extraction mechanism, factors influencing extraction efficiency, advantages, and disadvantages, and various applications of this method in pesticides, environmental cases, pharmaceuticals, food samples, forensic medicine, and more. The SBSE is an attractive alternative to traditional extraction methods, as it reduces solvent consumption, desorption costs, and extraction time. Its advantages include operational simplicity, good reproducibility, high recovery rates, and minimal use of organic solvents. In this review, 52 articles were selected for final analysis, with a portion of the results focusing on biological samples relevant to occupational toxicology. It can be concluded that this method is still in the early stages of widespread application, and many issues require further research. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.