(2025) Effects of transcranial direct current stimulation along with cognitive training on cognitive functions and activities of daily living in patients with Parkinson's disease: A pilot randomized controlled trial. Neurology and Clinical Neuroscience. pp. 29-36. ISSN 20494173 (ISSN)
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Abstract
Background: Cognitive impairment is one of the most common symptoms of Parkinson's disease (PD). In recent years, the effect of transcranial direct current stimulation (tDCS) have been investigated on various disabilities related to PD, including sensory and motor deficits and fatigue. Aim: To investigate effects of transcranial direct current stimulation (tDCS) along with cognitive training on attention, working memory, reaction time (RTI), response inhibition, and activities of daily living performance. Methods: This pilot randomized, single-blinded, and sham-controlled trial was performed on 32 people with PD who were blocked randomized equally into intervention and control groups. Intervention group received ten 20-min sessions of tDCS during ten 45-min sessions of cognitive training, while control group received ten 20-min sessions of sham-tDCS during ten 45-min sessions of cognitive training. Anodal electrode of tDCS (2 mA) was placed over left dorsolateral prefrontal cortex (DLPFC), while cathode was over right supraorbital region. A blinded assessor performed pretest, posttest, and follow-up assessments using the Unified Parkinson's Disease Rating Scale and four subtests of the CANTAB computer test including Match to Sample Visual Search, spatial span task, stop signal task, and RTI. Results: The results showed significant differences within groups over time in the mean scores of attention (F = 24.73, p = 0.00), working memory (F = 19.06, p = 0.000), RTI (F = 8.63, p = 0.005), response inhibition (F = 15.75, p = 0.000), and activity of daily living performance (F = 6.73, p = 0.013). Conclusion: tDCS (anodal electrode over the left DLPFC and cathodal electrode over the right supraorbital region) along with cognitive training could facilitate improvement of cognitive functions and activities of daily living performance compared to routine cognitive exercises in people with PD. © 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
| Item Type: | Article |
|---|---|
| Keywords: | activity of daily living attention cognitive function Parkinson's disease reaction time response inhibition transcranial direct current stimulation working memory adult aged Article assessment of humans bradykinesia brain depth stimulation CANTAB computer test cerebrovascular accident clinical article cognition cognitive defect cognitive rehabilitation controlled study cortical excitability daily life activity disease duration dorsolateral prefrontal cortex educational status electroencephalography executive function exercise fatigue female follow up functional magnetic resonance imaging Hamilton Depression Rating Scale human inhibitory control male Match to Sample Visual Search middle aged mild cognitive impairment Montreal cognitive assessment nerve cell plasticity neuropsychological assessment Parkinson disease pilot study prefrontal cortex primary motor cortex quality of life questionnaire randomized controlled trial spatial span task stop signal task trail making test training transcranial magnetic stimulation Unified Parkinson Disease Rating Scale |
| Page Range: | pp. 29-36 |
| Journal or Publication Title: | Neurology and Clinical Neuroscience |
| Journal Index: | Scopus |
| Volume: | 13 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1111/ncn3.12841 |
| ISSN: | 20494173 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/31680 |
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