Assessment of the Efficacy of Photodynamic Therapy in Patients with Central Serous Chorioretinopathy

Abstract

Background: Photodynamic therapy (PDT) is known as an effective method in central serous chorioretinopathy (CSCR) in recent years. The aim of this study was to determine the efficacy of PDT in patients with CSCR. Methods: This study was a prospective cohort study in patients with diagnosis of CSCR at the referral eye center. All necessary eye examinations and imaging for patients were done to diagnose the disease. The best corrected visual acuity (BCVA), contrast sensitivity at 3 and 6, 12 and 18 cycles per degree with CSV 1000 chart, color vision with Ishihara plates, central macular thickness (CMT) and central macular volume (CMV) was evaluated before and one month after PDT. Findings: Fifty-six eyes of 56 patients with a female to male ratio of 2.5:1 and mean age of 9.41 ± 3.7 were evaluated. Significant improvement in BCVA, CMT and CMV was observed. The changes in contrast sensitivity and color vision one month after the intervention were not statistically significant (p> 0.05). Conclusion: The most important results in the present study indicated that PDT has a significant improvement in patients' BCVA, CMT and CMV one month after PDT. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.