The association of abdominal obesity with the incidence of in-stent restenosis and thrombosis

Abstract

BACKGROUND: Given the association between obesity and increased risks of cardiovascular diseases, the acceleration of atherosclerosis, and the significance of patient outcomes after percutaneous coronary intervention (PCI), this study aimed to investigate the relationship between abdominal obesity and the incidence of in-stent restenosis (ISR) or stent thrombosis (ST) following PCI. METHODS: This cross-sectional study included 5,980 patients who underwent angioplasty at Chamran Specialty Heart Hospital from March 2023 to February 2025. Of this population, 105 patients who developed ISR or ST and returned to the hospital were evaluated. Their demographic and clinical characteristics were recorded, and waist circumference was measured to assess abdominal obesity. RESULTS: The findings revealed that ISR and ST occurred in 66 (86.8) and 10 (13.2) cases, respectively, among patients with abdominal obesity, whereas in patients without abdominal obesity, these complications were observed in 25 (86.2) and 4 (13.8) cases, respectively (P > 0.050). Additionally, the incidence of ISR or ST was reported to occur over a longer period in patients without abdominal obesity, whereas it was observed within a shorter timeframe after PCI in patients with abdominal obesity (P < 0.05). CONCLUSION: According to the results of this study, the prevalence of abdominal obesity was higher in patients with complications of ISR or ST after PCI. Also the incidence of ISR or ST occurred in a longer period of time in patients without abdominal obesity after PCI and in a shorter period of time after PCI in patients with abdominal obesity.