Comparison of Serum Vitamin D Levels in Clinically Isolated Syndrome Patients

Abstract

Background: Vitamin D deficiency is considered a modifiable risk factor in Clinically Isolated Syndrome (CIS), and early interventions to correct vitamin D levels may be an effective strategy in the management of these patients. Considering the role of vitamin D in cases of multiple sclerosis (MS), this study was conducted with the aim of comparing the level of vitamin D in patients with CIS and healthy population. Methods: In this case-control study, the vitamin D levels of 51 patients with CIS and 150 healthy individuals were measured and compared along with demographic and clinical data. Data were entered into analyzed using chi-square, t-test, and logistic regression tests. Findings: The mean serum level of vitamin D in the patient and control groups was 37.0 ± 13.8 and 38.8 ± 25.1 ng/dL, respectively, and the difference between the two groups was significant (P = 0.042). Conclusion: It seems that the serum level of vitamin D in patients with CIS is lower than in healthy individuals, suggesting that vitamin D may play a role in the pathogenesis of CIS. © 2025, Isfahan University of Medical Sciences(IUMS). All rights reserved.