Comparison the Effects of Two Different Doses of Dexmedetomidine and Propofol on Intraoperative Sedation; Hemodynamic Changes and Postoperative Complications in Patients Undergoing Ovarian Puncture Surgery

Abstract

Background:This study aimed to evaluate the effects of different doses of dexmedetomidine and propofol on sedation, hemodynamic changes, and postoperative complications in patients undergoing ovarian puncture surgery.Materials and Methods:This randomized controlled trial was conducted on 96 women candidates for ovarian puncture surgery. In the first group (DEX-0.5), a bolus dose of dexmedetomidine 0.5 mu g/kg was administered for the induction of anesthesia, followed by a maintenance dose of dexmedetomidine 0.5 mu g/kg/min. In the second group (DEX-1), a bolus dose of dexmedetomidine 1 mu g/kg was administered for induction, followed by a maintenance dose of dexmedetomidine 1 mu g/kg/min. In the third group (control group), propofol 50 mu g/kg/min was administered for induction of anesthesia.Results:SBP, DBP, and MAP were significantly lower in the control group compared to the other groups (P value < 0.05). The mean scores of patient and surgical satisfaction levels in the DEX-0.5 group were significantly higher than the control group (4.00 +/- 1.02 and 4.41 +/- 0.57, respectively) and in the DEX-1 group (6.00 +/- 1.35 and 4.61 +/- 0.56, respectively) compared to the control group (2.90 +/- 2.10 and 3.10 +/- 0.32, respectively) (P value < 0.05). Need for additional analgesics was significantly higher in the control group compared to the intervention groups (P value < 0.05).Conclusion:It seems that the administration of dexmedetomidine 1 <mu>g/kg, due to better pain relief, higher satisfaction, less need for additional analgesics, and minimal occurrence of complications, can be recommended as a safe and effective dose in ovarian puncture surgery.