Evaluation of the Sixth Exon of IL12RB1 in Patients Afflicted by the Non-Healing Form of Cutaneous Leishmaniasis

Abstract

Cutaneous Leishmaniasis (CL) appears as a localized skin lesion that is curable without any clinical intervention. However, Leishmania infection rarely manifests as non-healing lesions, persisting for many years. The current study aimed to assess the sixth exon of IL12RB1 in patients afflicted by the non-healing form of CL (NHCL). Leishmania infection was diagnosed through a direct smear. The sixth exon of the IL12RB1 was sequenced with no polymorphisms detected in the sixth exon of the IL12RB1 gene; therefore, suggesting that the sixth exon of IL12RB1 was not contributing to the NHCL phenotype.