(2025) Immune boosting by pharmaceutical C-phycocyanin, in vitro and in silico effects on peripheral blood mononuclear cells. Health Biotechnology and Biopharma. pp. 22-47. ISSN 25384414 (ISSN)
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Abstract
Developing drugs with low side effects in cancer therapy has been recently considered. Therefore, we investigated the impact of Spirulina-purified C-phycocyanin, which has the highest purity index of 28.8 and was patented in the World Intellectual Property Organization, on immune boosting. C-phycocyanin cell toxicity and proliferation effects (1,10,100, 250 µg/mL) were assayed. The flow cytometry confirmed that C-phycocyanin increased proliferation and decreased necrosis by 50 with no toxicity. Molecular docking revealed that the C-phycocyanin interacts with novel key cancer-related proteins in the apoptosis pathway, including CASPASE3, COX-2, JAK3, NFκB, and STAT3, with the lowest binding affinity (from -132.06 to -179.19 kcal/mol) and total energy (from -382.4 to -504.8 kcal/mol). Therefore, it can be concluded that C-phycocyanin might be an effective candidate as a biopharmaceutical in drug and prodrug design for cancer treatment and immune boosting. Copyright © 2025, Health Biotechnology and Biopharma. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | C-phycocyanin immune system molecular docking proliferation Spirulina platensis antineoplastic agent c phycocyanin caspase 3 cyclooxygenase 2 immunoglobulin enhancer binding protein Janus kinase 3 phycocyanin prodrug STAT3 protein unclassified drug adult antineoplastic activity apoptosis apoptotic cell percentage Arthrospira platensis Article binding affinity cell proliferation computer model controlled study cytotoxicity drug binding site drug isolation drug purification drug targeting dry powder flow cytometry human human cell hydrophilicity hydrophobicity immunopharmacology in vitro study MTT assay NF kB signaling nuclear localization signal peripheral blood mononuclear cell protein phosphorylation sediment World Intellectual Property Organization |
| Page Range: | pp. 22-47 |
| Journal or Publication Title: | Health Biotechnology and Biopharma |
| Journal Index: | Scopus |
| Volume: | 9 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.22034/HBB.2025.08 |
| ISSN: | 25384414 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/32715 |
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