(2025) Long non-coding RNA PART1 expression in breast cancer tumor tissues in Iran. Gazzetta Medica Italiana Archivio per le Scienze Mediche. pp. 192-196. ISSN 03933660 (ISSN)
Full text not available from this repository.
Abstract
BACKGROUND: Breast cancer is a serious threat to human health. Studies have shown that LncRNAs are associated with the progression of several cancers. The aim of this study was to investigate the presence and level of prostate androgen-regulated transcript 1 (PART1) expression in breast cancer tumor tissue compared to unchanged breast tissue in the same patients. METHODS: In this study, 50 breast tumor sample tissue of patients with invasive breast cancer and its normal adjacent tissue were included in the study. qRT-PCR was performed to examine the expression level of PART1. RESULTS: The study showed eight times higher PART1 expression in the tumors tissues compared to the normal tissues. The expression of PART1 LncRNA was higher in the HER2 overexpression subtype than in others. Also, its expression was inversely associated with estrogen receptor expression. CONCLUSIONS: Due to the expression rate of lncRNA PART1 in advanced stages of breast cancer, in the estrogen-negative group, and also in the HER-2 subtype, it can be used as a biomarker and targeted therapy option in breast cancer. © 2024 EDIZIONI MINERVA MEDICA.
| Item Type: | Article |
|---|---|
| Keywords: | Breast neoplasms PART-1 RNA, human RNA, long noncoding estrogen receptor long untranslated RNA adult Article bioinformatics breast cancer cancer prognosis cancer survival carcinogenesis clinical article denaturation differential gene expression disease free survival down regulation female gene gene expression gene expression profiling gene ontology histology human human tissue immunohistochemistry morbidity mortality mRNA expression level overall survival PART1 gene protein expression real time polymerase chain reaction real time reverse transcription polymerase chain reaction reverse transcription polymerase chain reaction RNA extraction RNA sequence tumor invasion tumor volume upregulation |
| Page Range: | pp. 192-196 |
| Journal or Publication Title: | Gazzetta Medica Italiana Archivio per le Scienze Mediche |
| Journal Index: | Scopus |
| Volume: | 184 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.23736/S0393-3660.24.05583-9 |
| ISSN: | 03933660 (ISSN) |
| Depositing User: | خانم ناهید ضیائی |
| URI: | http://eprints.mui.ac.ir/id/eprint/32899 |
Actions (login required)
 |
View Item |