The impact of oat (Avena sativa) consumption on biomarkers of renal function in patients with chronic kidney disease: A parallel randomized clinical trial

(2018) The impact of oat (Avena sativa) consumption on biomarkers of renal function in patients with chronic kidney disease: A parallel randomized clinical trial. Clinical nutrition (Edinburgh, Scotland). pp. 78-84. ISSN 1532-1983 (Electronic) 0261-5614 (Linking)

[img]
Preview
Text
3347.pdf

Download (468kB) | Preview

Abstract

BACKGROUND & OBJECTIVE: Animal studies report that oat (Avena sativa L) intake has favorable effects on kidney function. However, the effects of oat consumption have not been assessed in humans. The aim of this study was to examine the impact of oat intake on biomarkers of renal function in patients with chronic kidney disease (CKD). METHODS: Fifty-two patients with CKD were randomly assigned to a control group (recommended to reduce intake of dietary protein, phosphorus, sodium and potassium) or an oat consumption group (given nutritional recommendations for controls +50 g/day oats). Blood urea nitrogen (BUN), serum creatinine (SCr), urine creatinine, serum albumin, serum potassium, parathyroid hormone (PTH), serum klotho and urine protein concentration were measured at baseline and after an eight-week intervention. Creatinine clearance was calculated using urine creatinine concentration. RESULTS: Within group analysis showed a significant increase in BUN (P = 0.02) and serum potassium (P = 0.01) and a marginally significant increment in SCr (P = 0.08) among controls. However, changes in the oat group were not significant. In a multivariate adjusted model, we observed a significant difference in change of serum potassium (-0.03 mEq/L for oat group and 0.13 mEq/L for control group; P = 0.01) and a marginally significant difference in change of serum albumin (0.01 g/dl for oat group and -0.08 for control group; P = 0.08) between the two groups. There was no change in PTH concentration. CONCLUSION: Intake of oats may have a beneficial effect on serum albumin and serum potassium in patients with CKD. REGISTRATION CODE: Present study registered under IRCT.ir identifier no. IRCT2015050414551N2.

Item Type: Article
Keywords: Avena sativa Chronic kidney disease Oats Randomized clinical trial
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 145-220 Nutrition. Vitamins
WJ Urogenital System > WJ 300-378 Kidney
Divisions: Faculty of Health > Department of Epidemiology and Biostatistics
Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Food Security Research Center
Isfahan Kidney Diseases Research Center
School of Nutrition and Food Sciences > Department of Community Nutrition
Page Range: pp. 78-84
Journal or Publication Title: Clinical nutrition (Edinburgh, Scotland)
Journal Index: Pubmed, ISI
Volume: 37
Number: 1
Identification Number: https://doi.org/10.1016/j.clnu.2016.11.022
ISSN: 1532-1983 (Electronic) 0261-5614 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/3347

Actions (login required)

View Item View Item