FTO genotype, thiamine dietary intake, and risk of spontaneous abortion: A case-control study

Abstract

Background: Spontaneous Abortion (SA) is a prevalent challenge for maternal health. Polymorphism in some genes as well as deficiency of some vitamins can be effective in causing SA. This study aimed to investigate the relationship between SA and dietary intake of thiamine in individuals with different genotypes of FTO rs9939609 polymorphism. Methods: This case-control study was conducted in Tehran, Iran, and included 539 adult women between 20 and 40 years of age. The study included 192 women with a history of SA and 347 women without a history of abortion. Genotyping of FTO rs9939609 was performed using 5 mL of blood per participant and the Tetra ARMS-PCR method. The dietary intake of thiamin was assessed using a 168-item semi-quantitative food frequency questionnaire (FFQ). Result: Among carriers of the AA/AT genotype, an inverse association was observed between SA and dietary thiamine intake (OR = 0.315, 95 CI: 0.115-0.858, P = 0.024), which remained significant after adjustment for age, BMI, calorie intake, physical activity, and history of diabetes. No significant association was found among carriers of the TT genotype. Conclusions: These findings suggest that higher thiamine intake may reduce the risk of spontaneous abortion specifically among women carrying the AA/AT FTO genotype, but not among those with the TT genotype. Further studies are warranted.