Evaluation of Blood Inhibin-A Level in Pregnant Women on Pregnancy Outcome in Mothers Referred to Educational Hospitals in Isfahan City in 2021-2022

Abstract

Background: This study aimed to investigate the relationship between serum inhibin A levels in pregnant mothers and pregnancy outcomes in mothers referred to teaching hospitals in Isfahan in 2021-2022. Methods: This cross-sectional study was conducted among pregnant women at educational hospitals in Isfahan Province between March 2021 and March 2022. A total of 121 singleton pregnant women who underwent the second trimester quad screen test were included. Serum samples were collected and analyzed for inhibin A levels, which were expressed as multiples of the median. Adverse pregnancy outcomes, including preeclampsia, gestational diabetes mellitus (GDM), and neonatal complications, were assessed. Findings: Overall, 121 pregnant women with a mean age of 31.5 ± 4.9 years were enrolled. Statistically significant correlations were observed between elevated maternal serum inhibin A levels and adverse pregnancy outcomes. Notably, high inhibin A levels were associated with an increased incidence of preeclampsia (P < 0.001), neonatal intensive care unit (NICU) admission (P < 0.001), lower Apgar scores (P = 0.018), and intrauterine growth restriction (IUGR) (P = 0.013). Conclusion: Our findings suggest that maternal serum inhibin A level is a valuable predictor of adverse pregnancy outcomes. © 2026, Isfahan University of Medical Sciences(IUMS). All rights reserved.