Evaluating the relationship of serum level of magnesium at arrival to intensive care unit and mortality rate and inflamatory factors in patients with multiple trauma

Abstract

Background: Microelements deficiency in patients with multiple trauma in intensive care units are very important and can lead to severe complications and increased mortality and morbidity rates in these patients. Magnesium has various roles in the body but a few studies demonstrated its relationship with inflammatory factors and their impact on mortality rate in critically ill patients. This study was conducted to evaluate the relation of serum level of magnesium at arrival to intensive care unit and inflammatory factors and mortality rate in patients with multiple trauma. Methods: 80 patients multiple with trauma hospitalized in intensive care unit of Alzahra hospital, Isfahan, Iran, aged 16 to 85 years were included. Serum levels of magnesium, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 1 (IL1), interleukin 33 (IL33), and interleukin 6 (IL6) were measured. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were calculated for each patient. Pearson’s correlation test was used to analysis the relationship between these variables and serum level of magnesium. Findings: All 80 patients were included in final analysis. Mean magnesium level was 33.0 ± 69.1 mg/dl; 46 and 34 patients (57.5 and 42.5 percents) had low and normal levels of magnesium, respectively. Pearson’s correlation test showed lower levels of IL1 and higher levels of platelet, and serum sodium and potassium and bilirubin and longer duration of ventilation in hypomagnesemic patients. Conclusion: There is significant relationship between serum levels of IL1, sodium, bilirubin, and platelet, and duration of ventilation with serum level of magnesium and no relationship between and mortality rate of patients with multiple trauma and serum level of magnesium. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.