Comparing the hemodynamic effects of nitroglycerin and labetalol infusion for hypertension and heart rate control before and during induction to cardiopulmonary arrest in patients under coronary artery bypass graft

Abstract

Background: This study was aimed to compare the hemodynamic effects of nitroglycerin and labetalol infusion for hypertension and heart rate control in the before and during induction to cardiopulmonary arrest in patients under coronary artery bypass graft. Methods: In a clinical trial study, 70 candidates for coronary bypass were selected and randomly divided in the two groups. In the first group nitroglycerin and in the second group labetalol was injected and hemodynamic changes, blood gas levels, incidence of arythmia during and after surgery was measured. Also amount of anti-arythmic drugs, inotrop, pack cell and DC shock need were studied and compared between the two groups. Findings: Incidence of cardiac arrhythmia in the nitroglycerin and labetalol was 9 and 5 (25.7 VS 3.14) (P = 0.370), also need to anti-arrhythmic drugs in the two groups was 22.9 and 2.9, respectively (P = 0.028). Conclusion: Using labetalol in patients under coronary artery bypass graft is better than nitroglycerin for hemodynamic and blood gases. Also, incidence of cardiac arrhythmia during cardiopulmonary arrest is lower and labetalol is preferred to nitroglycerin and recommended according to surgeons and anesthesiologists. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.