The Effectiveness of Submucosal Injection Bioactive Vitamin B-12 in Comparison to Triaminolone in Pain and Frequency of Apthous Ulcer

Abstract

Aim: Previous study was observed the effects of systemic administration B-12 in frequency of aphthous. According to the therapeutic effects of B-12 include Master-Key, anti-inflammatory and analgesic, topical administration has the potential to decrease pain and the frequency of aphthous. Cyanocobalamin is needed to metabolize in the liver and there is no possibility to become active in submucosal injection so the purpose of this study was evaluate the effect of bioactiveVitamin B-12(methylcobalamin). Materials & Method: This clinical trial single-blind was performed on 40 patients whorandomlydivided into two groupsof 20 persons. The intervention group received submucosal injection B-12 (methylcobalamin) whereas the control group took a Triamcinolone. The pain and recovery time was calculated based on numeric scale and achieve to zero pain. Statistical analyses were performed using the SPSS version22 statistical software. The statistical analyses wereperformed using an analysis of variance, T-test and survival analysis alpha = 0/05 was considered to indicate statistical significance. Results: The results of this studyindicatespaindifferences between the two groups was not significanton the first day.(P= 0/716) The third day to sixth in the intervention group was significantly lower(P<0/05) Again after seventh day was significant differences in pain between the two groups(P > 0/05) and the recovery time is significantly lower in the intervention group.(P<0/001) Conclusion: his study indicatesthat submucosalinjection B-12 (methylcobalamin) is an effective treatmentfor aphthous stomatitiswhereas Triamcinolone.