(2016) Correlation between Serum Homocysteine Levels and Outcome of Patients with Severe Traumatic Brain Injury. World neurosurgery. pp. 507-515. ISSN 18788750 (ISSN)
Full text not available from this repository.
Abstract
Objective To examine the relationship between homocysteine (Hcy) plasma levels and the outcome of patients with traumatic brain injury (TBI). Methods In a prospective case-control study, demographic, clinical, and Glasgow Coma Scale score data were collected. Outcome was evaluated according to the Glasgow Outcome Scale score at the time of discharge from the hospital and 6 months after hospitalization. Plasma levels of Hcy were measured using high-performance liquid chromatography. Computed tomography scan of the brain was performed within the first 24 hours of hospitalization. Results The case group comprised 150 patients with TBI (men, 54.7; mean age, 55.90 years ± 12.31), and a control group comprised 150 healthy individuals (men, 52; mean age, 49.56 years ± 15.64) were studied. The mean ± SD plasma Hcy level in the TBI group (20.91 μmol/L ± 15.56) was significantly higher than plasma Hcy level in the control group (7.45 μmol/L ± 13.54, P = 0.000). There was a significant relationship between Hcy plasma levels and Glasgow Coma Scale score and computed tomography findings classified by the Marshall score. (P = 0.001 and P = 0.028, respectively). Also, there was a significant difference in mean Hcy plasma between patients who died as a result of TBI and patients who were still alive at the end of the study period according to Glasgow Outcome Scale score (P = 0.000 and P = 0.054, respectively). Conclusions There was a significant correlation in this study between plasma Hcy levels and severity of trauma and prognosis in patients with TBI. © 2016 Elsevier Inc. All rights reserved.
Item Type: | Article |
---|---|
Keywords: | Glasgow Coma Scale Homocysteine Key words CT scan Outcome Prognosis Traumatic brain injury adult aged amino acid blood level Article case control study computer assisted tomography controlled study disease severity female Glasgow outcome scale high performance liquid chromatography hospital discharge hospitalization human hyperhomocysteinemia major clinical study male neuroimaging prospective study blood Brain Injuries middle aged treatment outcome Case-Control Studies Humans Prospective Studies |
Page Range: | pp. 507-515 |
Journal or Publication Title: | World neurosurgery |
Journal Index: | Scopus |
Volume: | 87 |
Identification Number: | https://doi.org/10.1016/j.wneu.2015.09.016 |
ISSN: | 18788750 (ISSN) |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.mui.ac.ir/id/eprint/4215 |
Actions (login required)
View Item |