Relationship between serum resistin concentrations with metabolic syndrome and its components in an Iranian population

Abstract

Background: The aim of the study is to determine the association of resistin with each MetS component. Methods: This study had a case-control design, and its data was retrieved from the Isfahan Healthy Heart Program (IHHP), Serum samples from 44 subjects with MetS (diagnosed according to the NCEP-ATPIII criteria) and 46 healthy controls were analyzed for resistin using enzyme-linked immunosorbent assay. Association between serum resistin and levels of total (TC), low- (LDL-C) and high-density (HDL-C) lipoprotein cholesterol, triglycerides (TG), fasting blood sugar (FBS), waist circumference, body mass index, and systolic and diastolic blood pressures was determined. Results: Serum resistin levels were significantly higher in the MetS compared with control group (3.64 +/- 1.63, P = 0.040). Serum levels of resistin were found to be significantly correlated with levels of TC (r = -0.347; P = 0.027) and LDL-C (r = -0.311; P = 0.050), but not other components of MetS including systolic and diastolic blood pressure, TG, HDL-C and FBS (P > 0.05) in the MetS group, after adjustment for age, gender and BMI. No significant correlation between resistin and MetS components was observed in the control group (P > 0.05). Conclusion: Serum resistin levels are elevated in subjects with MetS and may be associated with the severity of this syndrome. (C) 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved.